This quest is an obvious cultural reference to Comedy Central's, Stephen Colbert. He has a segment on his show called, "Threat Down", where he counts down the top 5 threats to America, the world, etc. There is / was a long running joke about bears being the number one threat to America (and Stephen Colbert hating bears).
He is also alluded to in a Lord of the Rings Online quest having to do with bears as well.
The capitalization, punctuation, and spelling of the title of this article have been verified and are correct as-is. The LU33 update notes incorrectly referred to this quest as The Number One Threat to Butcherblock