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Poxrata is grouped with her friends Brudu, Grudu, and Krudu in the Tide Wall room ( -38, -10, -148 ) Copy/waypoint -38, -10, -148.
Make sure you have a water breathing spell or charm before starting this fight. The Fishbone Earring from the Heritage Quest Hadden's Earring works perfectly, although some other water breathing spells such as Watery Respite may not.
You may need to focus on Brudu, Grudu, and Krudu, ignoring the red that Poxrata emits. Poxrata will be mostly dead by the time you have both companions taken out. Alternatively, if you have plenty of DPS, you can simply burn Poxrata, and her friends disappear when she dies.
The three adds don't do much. Poxrata remains rooted in the center while they're alive, so you may choose to kill them off to the side. There is a KB. Poxrata summons a Crimson tide every so often-- it helps to have water breathing on since the room fills with water.
The only thing you really ought to pay attention to is Poxrata's Steal Essence-- the red text is, Poxrata begins life draining [you/name], but her reach is only 20 meters! As one might expect, if the person she life drains is standing outside of 20 meters, she won't heal.
