Most Lore and Legend Quests can be started either with a book or by examining one of the quest items. Find the book, Destroy All Vampires!, using the location information above. Next, read the book, Destroy All Vampires!, flip through all the pages, and accept the quest. Once you have accepted the quest you may place the book in your house. You do not need the book to progress the quest.
Steps
Find the following auto-updating pieces by killing vampires in any zone:
Vampire's Black Heart
Vampire's Hypnotic Eyes
Vampire Coffin Dust
Find and examine the following tradeable pieces obtained by looting vampires in any zone, or buying them from other players
20 vampiric incisors These are the only additional "body parts" needed.
The book is also available during Nights of the Dead. You MUST complete "There Will Be Ghosts..." in order to access the room the book is in. Once you have completed the quest, head back up from the basement and walk through the painting at the top of the stairs.
With the arrival of LU54, you can acquire the Vampire Lore and Legend quest, from examining any vampiric incisors. A good place to get the incisor(s) is from the vampire encampment ( -239, 5, -310 ) Copy/waypoint -239, 5, -310 in Dark Light Woods (just past the Fairy and Werewolf encampments).