Kaira ( -452, -6, 785 ) /waypoint -452, -6, 785 is near the Greenblood river where it splits around Alliz Temple, just up from the Restored Druid Ring and close to the Tae Ew Station. Kaira sends you to find the last two rune keys.
First key is at the Anaconda River, the first pile of rocks with reeds ( -528, -6, 204 ) /waypoint -528, -6, 204. Red and black box, and now gives off an intermittent blue/white sparkle to be seen easier in the water.
Return to Kaira and give her the key. She sends you to find the second key.
Second key is near Kaira's location in the Greenblood River ( -433, -16, 892 ) /waypoint -433, -16, 892.